Christos Davatzikos, Ph.D.

Wallace T. Miller Sr. Professor of Radiology,
and Electrical and Systems Engineering,
Director, Center for Biomedical Image Computing and Analytics
Director, Section of Biomedical Image Analysis
Joint Affiliations: Bioengineering and Applied Math graduate groups

University of Pennsylvania
Richards Building, 7th Floor
3700 Hamilton Walk
Philadelphia PA 19104
Tel.: 215-746-4067


Biomedical Image Analysis, Machine learning in Imaging, Imaging Biomarkers of Neurologic and Neuropsychiatric Diseases.


Ph.D.: Electrical and Computer Engineering, JHU, 1994
B.Sc.: National Technical University of Athens, Greece, 1989 (EE&CS)


For a full list of publications check here
    1. Habes M, Erus G, Toledo JB, Zhang T, Bryan N, Laune LJ, Rosseel Y, Janowitz D, Doshi J, Van der Auwera S, von Sarnowski B, Hegenscheid K, Hosten N, Homuth G, Völzke H, Schminke U, Hoffmann W, Grabe H, Davatzikos C. "White matter hyperintensities and imaging patterns of brain aging in the general population", Brain, 2016, In Press. DOI 10.1093/brain/aww008
    2. Dong, A, Honnorat, N, Gaonkar, B, Davatzikos, C, "CHIMERA: Clustering of heterogeneous disease effects via distribution matching of imaging patterns", IEEE Transactions on Medical Imaging, October 2015, [Epub ahead of print]
    3. Macyszyn, L, Akbari, H, Pisapia, JM, Da, X, Attiah, M, Pigrish V, Bi Y, Pal S, Davuluri RV, Roccograndi L, Dahmane N, Martinez-Lage M, Biros G, Wolf RL, Bilello M, O'Rourke DM, Davatzikos, C,"Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques" Neuro Oncology, July 2015, [Epub ahead of print]
    4. T. Zhang, N. Koutsouleris, E. Meisenzahl, C. Davatzikos, "Heterogeneity of Structural Brain Changes in Subtypes of Schizophrenia Revealed Using MRI Pattern Analysis", Schizophrenia Bulletin, 41(1), 74-84, January 2015, Epub 2014 Sep 26
    5. H. Eavani, T. D. Satterthwaite, R. Filipovych, R. E. Gur, R. C. Gur, C. Davatzikos, "Identifying Sparse Connectivity Patterns in the brain using resting-state fMRI", NeuroImage, 105, 286-99, January 2015, Epub 2014 Oct 2, PMCID: PMC4262564
    6. Erus G, Battapady H, Zhang T, Lovato J, Miller ME, Williamson JD, Launer, LJ, Bryan, RN, Davatzikos, C. "Spatial Patterns of Structural Brain Changes in Type-2 Diabetic Patients and Their Longitudinal Progression with Intensive Control of Blood Glucose", Diabetes Care, 38(1), 97-104, January 2015, Epub 2014 Oct 21, PMCID: PMC4274773
    7. G. Erus, H. Battapady, T.D. Satterthwaite, H. Hakonarson, R. E. Gur, C. Davatzikos, R. C. Gur, "Imaging Patterns of Brain Development and their Relationship to Cognition", Cerebral Cortex, January 2014, epub ahead of print
    8. H. Akbari, L. Macysyzn, X. Da, R. L. Wolf, M. Bilello, R. Verma, D. M. O'Rourke, C. Davatzikos, "Pattern Analysis of Dynamic Susceptibility Contrast MRI Reveals Peritumoral Tissue Heterogeneity", Radiology, 273 (2), 502-510, November 2014 PMCID: PMC4208985
    9. Ou, Y., Akbari, H., Bilello, M., Da, X., Davatzikos, C., "Comparative Evaluation of Registration Algorithms in Different Brain Databases With Varying Difficult: Results and Insights", IEEE Trans. On Medical Imaging, 33(10), pp. 2039-2065, October 2014
    10. R. A. Yotter, J. Doshi, V. Clark, J. Sojkova, Y. Zhou, D. F. Wong, L. Ferrucci, S. M. Resnick, C. Davatzikos, "Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden", Neurobiology of Aging, 34(12), 2835-2842, December 2013, PMCID: PMC3893024.
    11. X. Da, J. B. Toledo, J. Zee, D. A. Wolk, S. X. Xie, Y. Ou, A. Shacklett, P. Parmpi, L. Shaw, J. Q. Trojanowski, C. Davatzikos, ADNI, "Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers", NeuroImage, 4, 164-173, November 2013,  highlighted article, 2014, PMCID:PMC3871290
    12. Gaonkar, B., and C. Davatzikos. "Analytic estimation of statistical significance maps for support vector machine based multi-variate image analysis and classification", NeuroImage, 78,270-283, September 2013, PMCID: PMC3767485
    13. Sotiras, A., Davatzikos, C., Paragios, N., "Deformable Medical Image Registration: A Survey", Medical Imaging, IEEE Transactions on, 32,(7), pp.1153,1190, July 2013, PMCID: PMC3745275
    14. A. Gooya, K. Pohl, M. Bilello, L. Cirillo, G. Biros, E.R. Melhem, C. Davatzikos, "GLISTR: Glioma Image Segmentation and Registration", IEEE Transactions on Medical Imaging, 31(10), 1941-54, October 2012
    15. Weintraub D, Dietz N, Duda JE, Wolk D, Doshi J, Xie SX, Davatzikos C, Clark C, Siderowf A. "Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease", Brain, 135, 170-180, January 2012.
    16. N.K. Batmanghelich, B. Tasker, C. Davatzikos, "Generative-discriminative basis learning for medical imaging", IEEE Transactions on Medical Imaging, 31(1), 51-69, January 2012, (NIHMSID #385277), PMCID: PMC3402718
    17. Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ., "Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification", Neurobiology of Aging, 32(12), 2322.e19-2322.e27, December 2011
    18. L.J. Launer, J. Williamson, R.N. Bryan, M. Miller, R.M. Lazar, H.C. Gerstein, A.M. Murray, M.D., Sullivan, K.R. Horowitz, J. Ding, C. Truwit, J.L. Sunshine, J. Maldjian, J. Hirsch, L. Coker, L.C. Lovato, J. Lovato, C. Davatzikos,"Effects of randomization to intensive glucose lowering on brain structure and function in Type 2 Diabetes: ACCORD Memory in Diabetes Study", The Lancet Neurology, 10(11):969-77, November 2011
    19. T. Zhang and C. Davatzikos. "ODVBA: Optimally-Discriminative Voxel-Based Analysis", IEEE Transactions in Medical Imaging, 30(8), 1441-54, August 2011.
    20. Y. Ou, A. Sotiras, N. Paragios, C. Davatzikos, "DRAMMS: deformable registration via attribute matching and mutual-saliency weighting", Medical Image Analysis, 15(4), 622-639, August 2011, PMCID: PMC3012150
    21. Filipovych, R. and Davatzikos, C., "Semi-supervised Pattern Classification of Medical Images: Application to Mild Cognitive Impairment (MCI)", NeuroImage, 55
    22. (3), 1109-1119, April 2011
    23. A. Gooya, G. Biros, C. Davatzikos, "Deformable Registration of Glioma Images Using EM Algorithm and Diffusion Reaction Modeling", IEEE Transactions on Medical Imaging, 30(2), 375-390, February 2011, PMCID: PMC3245665
    24. J. Hamm, D. H. Ye, R. Verma, C. Davatzikos, "GRAM: A framework for geodesic registration on anatomical manifolds", Medical Image Analysis, 14 (5): 633-642, October 2010 (PMID: 20580597, PMCID: PMC2935207), Best paper award.
    25. Y. Wang, Y. Fan, P. Bhatt, and C. Davatzikos, "High-Dimensional Pattern Regression Using Machine Learning: From Medical Images to Continuous Clinical Variables", NeuroImage, 50(4): 1519-1535, May 2010
    26. E.I. Zacharaki, S. Wang, S. Chawla, D.S. Yoo, R. Wolf, E.R. Melhem, C. Davatzikos, "Classification of Brain Tumor Type and Grade Using MRI Texture and Shape in a Machine Learning Scheme", Magnetic Resonance in Medicine, 62(6):1609-1618, October 2009
    27. Y. Ou, D. Shen, J. Zeng, L. Sun, J. Moul, C. Davatzikos, "Sampling the spatial patterns of cancer: Optimized biopsy procedures for estimating prostate cancer volume and Gleason Score", Medical Image Analysis, 13(4): 609-620, # 3 Top 25 Hottest Articles in Computer Science Medical Image Analysis in July - September 2009, August 2009
    28. E.I Zacharaki, C.S Hogea D. Shen, G. Biros, C. Davatzikos, "Non-diffeomorphic registration of brain tumor images by simulating tissue loss and tumor growth", NeuroImage, 46(3):762-774, July 2009
    29. Davatzikos, C., Xu, F.; An, Y.; Fan, Y.,Resnick, S.,. "Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index", Brain, 132 (8): 2026-2035, May 2009
    30. S. Baloch, R. Verma, H. Huang, P. Khurd, S. Clark, P. Yarowsky, T. Abel, S. Mori, C. Davatzikos, "Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor images", Cerebral Cortex, 19(3): 675-687, March 2009
    31. C. Hogea, C. Davatzikos, and G. Biros, "Brain-tumor interaction biophysical models for medical image registration", SIAM J. Sci., 30 (6), pp. 3050-3072, October 2008
    32. C. Davatzikos, S.M. Resnick, X. Wu, P. Parmpi, C.M. Clark, "Individual patient diagnosis of AD and FTD via high-dimensional pattern classification of MRI", Neuroimage, 41(4):1220-1227. Epub 8 April 2008, July 2008
    33. C. Davatzikos, Y. Fan, X. Wu, D. Shen, S.M. Resnick, "Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging", Neurobiology of Aging, 29(4):514-523, April 2008
    34. Fan, N. Batmanghelich, C.M. Clark, C. Davatzikos and the Alzheimer's Disease Neuroimaging Initiative, "Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline", Neuroimage, 39 (4): p. 1731-1743, February 2008, (one of the top 10 cited papers of 2008)
    35. Y. Fan, R.E. Gur, R.C. Gur, D. Shen, M.E. Calkins, C. Davatzikos, "Unaffected Family Members and Schizophrenia Patients Share Brain Structure Patterns: a High-Dimensional Pattern Classification Study Biological Psychiatry", Biological Psychiatry, 63(1):118-124, January 2008
    36. R. Verma, P. Khurd, C. Davatzikos, "On Analyzing Diffusion Tensor Images by Identifying Manifold Structure using Isomaps", IEEE Transactions on Medical Imaging, 26 (6): 772-778, June 2007.
    37. Y. Zhan, D.Shen, J. Zeng, L. Sun, G. Fichtinger, J. Moul, C. Davatzikos, "Targeted Prostate Biopsy Using Statistical Image Analysis", IEEE Transactions on Medical Imaging, 26(6):779-788, 2007.
    38. Y. Fan, D.Shen, R.C. Gur, R.E. Gur, and C. Davatzikos, "COMPARE: Classification Of Morphological Patterns using Adaptive Regional Elements", IEEE Trans. on Medical Imaging, 26(1), 93-105, 2007.
    39. B. Karacali, C. Davatzikos, "Simulation of Tissue Atrophy Using a Topology Preserving Transformation Model", IEEE Transactions on Medical Imaging, 25(5): 649- 652, 2006.
    40. Z. Xue, D. Shen, B. Karacali, J. Stern, D. Rottenberg, C. Davatzikos, "Simulating deformations of MR brain images for validation of atlas-based segmentation and registration algorithms", NeuroImage, 33(3):855-866, 2006.
    41. Z. Xue, D. Shen, C. Davatzikos, "Statistical Representation of High-Dimensional Deformation Fields with Application to Statistically-Constrained 3D Warping Medical Image Analysis", Medical Image Analysis, 10(5):740-751, 2006.
    42. T. Beresford, D. B. Arciniegas, J. Alfers L. Clapp, B. Martin, Y. Du, D. Liu, D. Shen, and C. Davatzikos, "Disulfiram adherence preserves total hippocampus volume during the first 6 months of abstinence", ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 30, Suppl. S, pp. 190A-190A, 2006.
    43. A. Mohamed, D. Shen, E. Zacharaki, C. Davatzikos, "Deformable Registration of Brain Tumor Images via a Statistical Model of Tumor-Induced Deformation", Medical Image Analysis, 10(5), 752-763, 2006.
    44. J. N. Giedd, L.S. Clasen, R. Lenroot, D. Greenstein, G.L. Wallace, S. Ordaz, E.A. Molloy, J.D. Blumenthal, J.W. Tossell, C. Stayer, C.A. Samango-Sprouse, D. Shen, C. Davatzikos, D. Merke, G.P. Chrousos, "Puberty-related influences on brain development", Molecular and Cellular Endocrinology, 254-255, 154-162, July 2006.
    45. Z. Xue, D. Shen, C. Davatzikos, "CLASSIC: Consistent Longitudinal Alignment and Segmentation for Serial Image Computing", NeuroImage, 30(2):388-399, 2006.
    46. C. Davatzikos, D. Shen, R.C. Gur, X. Wu, D. Liu, Y. Fan, P. Hughett, B.I., Turetsky, R.E., Gur, "Whole-brain morphometric study of schizophrenia reveals a spatially complex set of focal Abnormalities", JAMA Archives of General Psychiatry, 62, 1218-1227, 2005.
    47. C. Davatzikos, M. Acharyya, K. Ruparel, D.G. Shen, J. Loughhead, R.C. Gur, and D. Langleben, "Classifying spatial patterns of brain activity for lie-detection", NeuroImage, 28(3): 663-668, 2005.
    48. R. Verma, S. Mori, D. Shen, P. Yarowsky, C. Davatzikos, "Spatiotemporal maturation patterns of murine brain quantified via diffusion tensor MRI and deformation-based morphometry", Proceedings of the National Academy of Sciences (PNAS) 102(19): 6978-6983, May 2005.
    49. C. Davatzikos, "Why Voxel-Based Morphometric Analysis Should be Used with Great Caution When Characterizing Group Differences", NeuroImage, 23,17-20, 2004.
    50. T. Liu, D. Shen, C. Davatzikos,"Deformable registration of cortical structures via hybrid volumetric and surface warping", NeuroImage, 22, 1790-1801, 2004.
    51. D. Shen, C. Davatzikos, "Measuring Temporal Morphological Changes Robustly in Brain MR Images Via 4-Dimensional Template Warping", NeuroImage, 21, 1508-1517, April 2004.
    52. B. Karacali, C. Davatzikos, "Estimating Topology Preserving and Smooth Displacement Fields", IEEE Transactions on Medical Imaging, 23(7), p. 868-880, 2004
    53. D. Xu, S. Mori, D. Shen, P.C.M. van Zijl, and C. Davatzikos, "Spatial normalization of diffusion tensor fields", Magnetic Resonance in Medicine, 50, 175-182, 2003.
    54. Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C, "Longitudinal MRI studies of older adults: a shrinking brain", Journal of Neuroscience, 23(3), 295-301, 2003.
    55. J. Ashburner, J.G. Csernansky, C. Davatzikos, N.C. Fox, G. B. Frisoni, P.M. Thompson, "Computer-assisted imaging to assess brain structure in healthy and diseased brains", The Lancet (Neurology), 2, 79-88, 2003.
    56. D. Shen, C. Davatzikos, "HAMMER: Hierarchical Attribute Matching Mechanism for Elastic Registration", IEEE Transactions on Medical Imaging, 21(11):1421-1439, 2002.
    57. C. Davatzikos , S.M. Resnick, "Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging", Cerebral Cortex, 12767-771, 2002. Appeared as one of the highlights in August's Nature Neuroscience Reviews issue.
    58. C. Davatzikos, A. Genc, D. Xu, S.M. Resnick, "Voxel-Based Morphometry Using the RAVENS Maps: Methods and Validation Using Simulated Longitudinal Atrophy", NeuroImage, 14, 1361-1369, December 2001 Used for this issue's cover.
    59. S.M. Resnick, A.F. Goldszal, C. Davatzikos, S. Golski, M.A. Kraut, E.J. Metter, R.N. Bryan and A.B. Zonderman, "One-year age changes in MRI brain volumes in older adults", Cerebral Cortex, 10, 464-472, 2000.
    60. C. Davatzikos and J.L. Prince, "Convexity Analysis of Active Contour Problems", Image and Vision Computing Journal, 17(1):27-36, January 1999.
    61. C. Davatzikos, "Mapping Image Data to Stereotaxic Spaces: Applications to Brain Mapping", J. Human Brain Mapping, 6, 334-338, 1998.
    62. C. Davatzikos and S.M. Resnick, "Sex differences in anatomic measures of interhemispheric connectivity: correlations with cognition in women but not in men", Cerebral Cortex, 8, 635-640, October/November 1998.
    63. C. Davatzikos, "Spatial Transformation and Registration of Brain Images Using Elastically Deformable Models", Special issue of Comp. Vis. and Image Understanding on Med. Imag., 66(2), 207-222, May 1997.
    64. C. Davatzikos and R.N. Bryan, "Using a deformable surface model to obtain a shape representation of the cortex", IEEE Transactions on Medical Imaging, 15, 785-795, Dec. 1996.
    65. C. Davatzikos, J.L. Prince and N. Bryan, "Image Registration Based Boundary Mapping", IEEE Transactions on Medical Imaging, 15(1):112-115, February 1996.
    66. C. Davatzikos, M. Vaillant, S. Resnick, J.L. Prince, S. Letovsky and R.N. Bryan, "A Computerized Method for Morphological Analysis of the Corpus Callosum", J. of Comp. Asstd. Tomography, 20(1): 88-97, January/February 1996.